Bionic leg restores natural walking speeds and steps: ‘I didn’t feel like my leg had been amputated’ | CNN (2024)


Amy Pietrafitta has learned to walk seven times.

First was as a child and then after an industrial burn led to the amputation of her left leg in 2018. Since then, she’s had “first steps” in prosthetic legs for running, water, high heels, rowing and everyday walking.

Her latest “first steps” were different. This time, she was fitted with a bionic leg that was fully connected to her brain, allowing her to walk and move like anyone else. With this new leg, she said, she couldn’t even tell there was a difference.

“I didn’t feel like my leg had been amputated,” the 47-year-old from Massachusetts said. “It was the happiest moment in my life.”

Pietrafitta was part of a study of a new neuroprosthesis from the Massachusetts Institute of Technology that’s fully controlled by the nervous system. Her leg had been amputated using a novel muscle-pairing technique called agonist-antagonist myoneural interface, or AMI, which preserves signaling between the muscles and the brain.

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The neuroprosthesis uses sensors placed between the reconstructed amputation site and the bionic leg to transmit electrical signals from the brain. This allows the prosthetic to sense its position and movement and to send this information back to the patient, enabling a sense of proprioception: the brain’s ability to sense self-movement and location in space.

The study,published Monday in the journal Nature Medicine, indicated that participants who’d had the specialized amputation and neuroprosthesis increased their walking speed 41%, matching the ranges and abilities of people without leg amputations. The results also suggested that the bionic limb could be controlled using just 18% of natural proprioception.

This is the first bionic leg fully controlled by the human nervous system to demonstrate natural walking speeds and gait patterns, according to Dr. Hugh Herr, principal investigator and senior author of the study and co-lead of theYang Center for Bionicsat MIT, where the research took place.

“It feels natural, as if the limb were made of flesh and bone. It’s as if the central brain isn’t aware the limb is amputated because the brain is getting normal sensations,” said Herr, who had both legs amputated below the knee after a climbing accident in 1982.

Bionic leg restores natural walking speeds and steps: ‘I didn’t feel like my leg had been amputated’ | CNN (2)

Dr. Hugh Herr in the lab. Herr had both legs amputated below the knee after a climbing accident in 1982.

Herr embarked on the project after observing a trend of prosthetics being increasingly controlled by robotic algorithms rather than the human nervous system.

“We want to rebuild human bodies,” he said. “We want to reconstruct and give people back what they so seek. We don’t just want to build fancier and fancier robotic tools or devices.”

To test the interface, 14 participants were split into two groups and fitted with bionic prosthetic legs. Seven had undergone AMI surgery, and seven had not.

The results suggested that those with AMI amputations navigated real-world environments better, including slopes, stairs, obstructed pathways and even an “American Ninja Warrior”-style course, according to Pietrafitta and Dr. Matthew J. Carty, the lead surgeon in the first AMI procedure and a co-author of the new study.

“This is a fundamental paradigm shift in the way we think about amputation in conjunction with technology: treating it as a restorative procedure as opposed to a failure,” Carty said.

Beyond first steps

The technology also allows users to switch between speeds without changing prosthetics. This reduces the hassle of swapping legs, avoids unwanted attention and restores a sense of normalcy, according to Pietrafitta.

“It felt normal. … I was ready to run. I kept wanting to take my hands off [the supports], to get out and start moving,” she said.

Restoring a normal gait is about more than getting from point A to point B. According to Pietrafitta, it’s about re-entering society.

GoodLifeStudio/E+/Getty Images Related article Gait speed is one of your vital signs, so make sure yours is OK

“It meant my life could begin again. … I could go out there and live the way I wanted to,” she said. “When you’re in your home and you’re bedridden, family and friends start to dwindle away. It’s too hard for people to come in and see you in pain.”

For John Rheinstein, a lower and upper limb prosthetic specialist and clinic manager at the Hanger Clinic in New York, the physical prosthesis is only part of a successful amputation outcome.

“Care has improved over the years (in part) as a result of advances in understanding and treating the emotional impacts of losing a limb,” he wrote in an email.

Is innovation accessible?

An estimated 1.9 million Americans live with limb loss, a figure expected to double by 2050, largely due to increasing rates of diabetes, a known risk factor, according to a 2018 report published by the federalAgency for Healthcare Research and Quality.

Herr said his team aims to make fully neuro-controlled prosthetics commercially available within five years. However, the 2018 report estimates that fewer than half of people with amputations receive prosthetic prescriptions.

People with amputations may struggle to get prescriptions and insurance coverage for prosthetic devices, especially for options with more advanced technology. Rheinstein cites insurance coverage for prosthetic limbs — specifically the lack of coverage for activity-specific prosthetics — as one of the most difficult parts of his patients’ rehabilitation journeys.

Bionic leg restores natural walking speeds and steps: ‘I didn’t feel like my leg had been amputated’ | CNN (4)

A study participant walks up stairs using a novel prosthetic leg.

“Demonstrating to payers the value of the outcomes we provide and how outcomes-based prosthetic care reduces overall healthcare costs” is one of the biggest challenges the industry faces today, he said.

For example, theBionX emPOWER prosthetic is the only motor-driven prosthetic on the market, according to Herr, and many people with limb loss aren’t able to access it.

Although AMI neuroprostheses aren’t available to the public, the AMI surgery has been performed on about 60 people around the world, according to Herr.

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    At the Brigham and Women’s Hospital in Boston, where Carty is a staff surgeon in the Division of Plastic Surgery, AMI is now the standard of care for amputations, Carty said.

    “The [hospital’s] ethical board determined it’s unethical to offer the standard amputation, because we now know the AMI amputation is so beneficial,” Herr said. “We hope it’ll be standard not only in Boston, but in clinical sites all over the world.”

    The more surgeons, prosthetists, researchers and patients work together on new developments, the better, according to Rheinstein, who hopes the AMI technique will “bring attention to the importance of thoughtfully planned amputation surgery to a patient’s successful rehabilitation.”

    “Hollywood for decades has given us visions of these remarkable bionic humans … but science reality has been slower than science fiction,” Herr added.

    “We’re finally producing systems that we’ve seen in the movies.”

    Bionic leg restores natural walking speeds and steps: ‘I didn’t feel like my leg had been amputated’ | CNN (2024)


    Bionic leg restores natural walking speeds and steps: ‘I didn’t feel like my leg had been amputated’ | CNN? ›

    The study, published Monday in the journal Nature Medicine, indicated that participants who'd had the specialized amputation and neuroprosthesis increased their walking speed 41%, matching the ranges and abilities of people without leg amputations.

    What happens if you don't amputate a dead limb? ›

    Tissue in the leg will die due to lack of oxygen and nutrients, which leads to infection and gangrene. In some cases, gangrene can be very dangerous as the infection can spread through the body and become life-threatening.

    Do people with prosthetics limp? ›

    Leg amputees, particularly those with higher levels of amputation, will often have some degree of a limp. When they limp, they are actually bending their upper bodies sideways in order to put their weight over the artificial leg.

    What does it feel like to lose a limb? ›

    Losing a limb can be a profound shock. Everyone reacts to loss in different ways. You may be feeling angry, frustrated, scared, sad, or lonely. These are very common feelings after limb loss.

    Can you refuse to have your leg amputated? ›

    Yes, a patient can refuse to get amputated. However, you might be at risk of severe infection, followed by the worsening of your condition, and severe pain. We suggest that you discuss all potential outcomes and treatment options with your doctor so that you can make an informed decision.

    What happens if you don't amputate necrotic tissue? ›

    Gangrene can lead to serious complications if it's not immediately treated. Bacteria can spread quickly to other tissues and organs. You may need to have a body part removed (amputated) to save your life.

    Can people with prosthetics walk normally? ›

    Some people still need a cane, walker or crutches to walk with a prosthetic leg, while others can walk freely.

    How much does a bionic leg cost? ›

    For those without health insurance, a basic prosthetic leg can cost less than $10,000, while a more advanced, computerized prosthetic leg controlled by muscle movements can cost up to $70,000 or more. Various non-profits provide financial aid or free prosthetic limbs for patients in need.

    What do hospitals do with amputated limbs? ›

    According to the standard procedure, there are two options for the Pathology department following the examination: the removed body part is used for medical research or it is disposed of as what is called "specific hospital waste". This waste is then disposed of together with other hospital waste.

    How painful is it to have a leg amputated? ›

    Many people who have an amputation experience some degree of stump pain or "phantom limb" pain. Stump pain can have many different causes, including rubbing or sores where the stump touches a prosthetic limb, nerve damage during surgery and the development of neuromas.

    Can I ask for my amputated limb? ›

    It's uncommon for surgery patients to ask, Annas said, but in general, those body parts are still considered their property. So, why would a doctor or hospital administrator try to deny a request? They might not want to bother with retrieving the part.

    Can you still feel an amputated leg? ›

    Amputees often report the phenomenon of “phantom limbs”, where they can still sense the presence of missing fingers, hands, arms, feet or legs, and even feel pain where the amputated parts once were. So far, science has had no explanation for this phenomenon.

    What is the life expectancy of a person with an amputated leg? ›

    According to Holbrook the average three-year survival rate after amputation is about 50 percent while the average five-year survival rate is 39-68 percent. Additionally, up to 55 percent of patients who underwent amputation as a result of medical conditions may require a second amputation within two to three years.

    Should I cut off dead limbs? ›

    Dead branches are not helpful to the tree as they might prevent it from healing properly and, at the same time, allow pests and diseases to invade the tree. Think of the bark of a tree as your skin. If you're hurt, the open wound paves the way for pathogens to come through.

    Do you have to amputate a crushed limb? ›

    Crush injuries often see severe damage to muscles, nerves, skin, bone, and other organs. A crush victim may need amputation, become paralyzed, or die as a result of their injuries.

    How long can a severed limb survive? ›

    Parts without major muscle groups, such as the fingers, have been replanted up to 94 hours later, although 12 hours is typically the maximum ischemic time tolerated. Parts that contain major muscle groups, such as the arms, need to be replanted within 6–8 hours to have a viable limb.

    What happens if you don't amputate a leg in diabetes? ›

    Because of reduced blood flow, wounds may be slow to heal or not heal at all. As a result, tissue can become damaged, and an infection can develop and spread to the bones. Once this happens, amputation is often the only option to prevent more damage.


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